Food Focus: Tomatoes, Friend or Foe?
Nightshades come up a lot in the autoimmune world, especially tomatoes. They’re often labeled as inflammatory, but the reality is more nuanced.
Nightshades include tomatoes, peppers, eggplant, and white potatoes. They contain natural plant compounds that help protect the plant. The concern is whether those compounds can contribute to inflammation in some people with autoimmune disease.
There is no strong evidence showing that nightshades worsen rheumatoid arthritis across the board. In fact, studies looking at tomatoes specifically do not consistently show increases in inflammatory markers like CRP or IL-6. Some research even suggests tomatoes may lower certain inflammatory signals.
So where does the controversy come from?
Most of it comes from gut-focused research and individual experience. Some compounds in certain nightshades, particularly potatoes, have been shown in lab and animal studies to irritate the gut lining in susceptible systems. That may help explain why some people with autoimmune conditions feel better when they reduce nightshades, even though this isn’t universal.
This is where personal experimentation is key.
I can honestly say I avoided nightshades for a long time. After looking at the research, I slowly reintroduced them and realized they don’t cause issues for me. I don’t avoid them, but I also don’t center my meals around them.
If tomatoes work for you, there’s no reason to force their removal. If they consistently leave you feeling worse, it’s reasonable to limit them without turning it into a hard rule.
If you’re curious about reducing tomatoes for a bit, having good swaps makes the process feel supportive instead of stressful. That’s exactly what the recipes below are designed to do.
Tomato-Free, Anti-Inflammatory Recipes

Beet & Pumpkin Seed Power Bowl
A nourishing grain-free bowl using roasted beets for richness and pumpkin seeds for texture.
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Butternut Squash & Herb Sheet-Pan Chicken
A simple, anti-inflammatory sheet-pan meal using roasted squash for natural sweetness and depth.
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Lemon Dill Fish Soup with Carrots & Squash
A light, anti-inflammatory fish soup that uses carrots and squash to add body and flavor.
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Nutrition Challenge
For the next 7 days, try limiting nightshades, especially tomatoes. Notice how you feel.
Use the recipes above when it helps. If you eat tomatoes anyway, that’s fine. This isn’t about restriction. It’s about awareness.
Pay attention to a few simple things:
- Joint stiffness
- Energy
- Digestion
At the end of the week, ask yourself: Do I feel any different?
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